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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 65-year-old woman on chronic hemodialysis presents with difficulty breathing and inability to sleep. The patient has had shortness of breath, diaphoresis, and nausea, but has not vomited.
She denies having abdominal pain, diarrhea, or chest pain. She has tachycardia and tachypnea, and exhibits peaked T waves with occasional PVCs on the ECG. Serum chemistry values are:
* Sodium: 137 mEq/L
* BUN: 125 mg/dL
* Potassium: 7.2 mEq/L
* Creatinine: 12.8 mg/dL
* Chloride: 97 mEq/L
* Glucose: 95 mg/dL
* HCO3- : 11 mEq/L
* Calcium: 8.5 mg/dL
* Albumin: 3.1 g/dL
* Phosphorus: 1.7 mg/dL
Which of the following should the pharmacotherapy specialist recommend for immediate therapy?

A) Sodium polystyrene sulfonate with sorbitol orally
B) Hemodialysis
C) Calcium gluconate intravenously
D) Sodium bicarbonate intravenously

2. A 59-year-old man presents to the neurology clinic with recently diagnosed Parkinson's disease.
At his last visit 2 months ago, selegiline therapy was instituted, and he is tolerating it well. The patient still complains of tremor and rigidity that are interfering with both professional and leisure activities. Which option is most appropriate at this time?

A) Change to carbidopa/levodopa.
B) Change to amantadine.
C) Change to ropinirole.
D) Change to entacapone.

3. A 25-year-old woman who is HIV-positive and has a CD4+ count of 120 cells/mm begins antiretroviral therapy. The patient's CD4+ count drops to 45 cells/mm3 over the next year. For which of the following opportunistic infections should this patient receive prophylaxis?

A) Mycobacterium tuberculosis and CMV
B) Mycobacterium tuberculosis and Pneumocystis Jirovecii pneumonia
C) MAC and Candida
D) MAC and Pneumocystis jirovecii pneumonia

4. A 65-year-old man with heart failure is currently receiving digoxin, lisinopril, furosemide, and carvedilol. He is in normal sinus rhythm and is hemodynamically stable. His left ventricular ejection fraction is 30%. Which of the following statements best describes the role of digoxin therapy in this patient?

A) It can be safely discontinued.
B) It can decrease the risk of hospitalization.
C) It can be synergistic with carvedilol.
D) It can improve mortality.

5. From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?

A) Crossover design comparing the new therapy with the best standard therapy
B) Placebo-controlled, randomized, parallel design
C) Parallel design comparing the new therapy with the best standard therapy
D) Placebo-controlled, crossover design

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